Rulide (roxithromycin)

Rulide is an antibiotic of the macrolide class manufactured by sanofi-aventis. Rulide is used in the treatment of mild to moderate bacterial infections. The active ingredient for rulide is roxithromycin discovered by rousseluclaf in 1987. Roxithromycin is also branded as rulid by sanofi-aventis in some countries like belgium, bulgaria, france, georgia etc. The ingredient used in the production of rulid, also rulide is extracted from erythromycin. Rulid has been used successfully in the treatment of bacterial infections in many parts of the body to include severe sore throat (pharyngitis), pneumonia, sinusitis, soft tissue infections, tonsillitis, impetigo (sores on the skin), severe bronchitis (coughing as a result of bronchial infection), non-gonococcal urethritis, and exacerbation of chronic bronchitis. Rulide (roxithromycin) is currently under clinical trials for the treatment of male-pattern hair loss.Rulide is not effective in the treatment of viral or fungal infections. Rulide is only prescribed after a qualitative evaluation of medical history. It is usually prescribed for use within the period of 5 to 70 days depending on the infection (treatment of chronic osteomyelitis with rulide has the longest duration). Rulide comes in tablets or in suspension. It should not be abused or taken less than the duration prescribed to avoid relapse or return of the infection.

Mechanism of action

Rulide(roxithromycin) prevents the fabrication of very important proteins (50s subunit of the 70s ribosome) necessary for the growth or/and survival of bacteria. This prevention disables the life-line of any bacterial infection to promote healing.Rulide has a half-life of about 12 hours in healthy adults, 20hours in children below 35kg and about 18 – 27 hours in adults with impaired hepatic function, adults with renal insufficiency, and elderly parents.

Rulide tablets

Rulide tablets 300mg and rulide 150mg are the usual rulide dosages. Each rulide tablet contains the following ingredient within the inside and coating, apart from the main ingredient, roxithromycin.

  • Tablet core: colloidal anhydrous silica, corn starch, talc, magnesium, pluronic f68, hydroxypropyl cellulose, magnesium stearate, and talc.
  • Tablet coating: anhydrous glucose, methyl hydroxyl-propylcellulose,titanium dioxide, and propylene glycol.

How to use rulide and duration

Rulide is taken orally and strictly as prescribed by the health providing center. Healthy adults usually take the rulide 300mg once in a day or rulide 150mg twice in a day with plenty of water; morning and evening before meals. Rulide dose in children, aged patients or patients with other health conditions is to be determined by the health provider as they require taking a less rulide dose. Some children may be required to take rulide 150 in a whole day in halves; twice. The rulide tablets 300mg is not to be taken by the children below the weight of 35kg or patients with other health issues. Children below the age of 12 years old are recommended to take rulid suspension, about 7mg per kg each day.

Infection Duration
Respiratory pathology 5 – 12 days
Otolaryngology 5 – 12 days
Chlamydia 12 – 14 days
Legionella pneumonia 21 days
Mycoplasma pneumonia 14 days
Chronic osteomyelitis 56 – 70 days

Your doctor should be duly informed if you have severe liver disease or taking other medications related to heart rhythm disorders, sleep disturbances, gastrointestinal disorders. Please do not take rulide if you are pregnant or breastfeeding a child.


A small quantity of rulide is metabolized and passed out as air through the lungs, feces or urine.

Possible side effects

Just like other antibiotics, rulide has side effects proven from clinical trials to include nausea, pancreatitis, vomiting, skin flushing, confusion, loss of appetite, rash, smell or taste of inversion, dizziness, pain in the epigastric region, migraines, diarrhea (usually with no blood), hallucinations, flatulence among others. Please notify your doctor or health provider immediately if you notice any of the side effects.